REVIEW - SCIENCE INSIGHTS 2015; 12(1):384-390.

Science Insights, Volume 12, No. 1, Pages 384-390, 21 April 2015 


Epigenetic Modification of Nociceptive Mediators: Implications for the Etiology of Neural Hypersensitivity (Part I)

Journal Science INSIGHTS
Publisher The BASE
ISSN pISSN 2372-8191  ||  eISSN 2329-5856
Subject Neuroscience
Category Review
Pages 384-390
Online Date APRIL 21, 2015
Copyright Copyright © 2015 BASE ¦¦ All rights reserved.


Epigenetic Modification of Nociceptive Mediators: Implications for the Etiology of Neural Hypersensitivity (Part I)

Mary K. Pathak,*,1 Liming Lei,†,1 Nan Wang,†,1 Maria L. Bolick,* Wei Wang, Shan-Wu Feng, Aili Sunny,* Xian Wang, Xiaofeng Shen, Shiqin Xu,†,∆ Fuzhou Wang,*,†,∆

*: Bonoi Academy of Science and Education (BASE), Winston-Salem, NC 27103, USA
†: Department of Anesthesiology, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing 210004, China
1: These authors contributed equally to this work.
∆: Correspondence to: Dr. Shiqin Xu, Tel: +86-25-5222 6112, Email: Or Dr. Fuzhou Wang, Tel: +1-336-734-3247, Email:

Science Insights 2015; 12(1):384-390. DOI:


Many factors have been identified contributing to the pathogenesis of pain, whereas we still cannot conquer the pain based on these findings suggesting that further studies are needed and other more potent mediators should be investigated. Epigenetics, in contrast to genetics, refers to the functionally relevant modifications to the genome that do not cause changes in underlying DNA sequence. These kinds of changes in gene expression or cellular phenotype regarded as landmarks of epigenetics are regulated by different types of modifications including gene methylation, histone acetylation, phosphorylation, imprinting and reprogramming etc. We, in this part (Part I), will review the general epigenetic modifications on molecular mediators on biological processes as the preface of the second part of the whole article (Part II will be available in the June issue of the journal). This general understanding of the epigenetic modification on the modulating factors that influence individual differences from pain sensitivity and responsiveness to analgesics possesses crucial clinical implications.■

Copyright © 2015 The BASE. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite This Paper: Pathak MK, Lei L, Wang N, Bolick ML, Wang W, Feng SW, Sunny A, Wang X, Shen X, Xu S, Wang F. Epigenetic modification of nociceptive mediators: implications for the etiology of neural hypersensitivity (Part I). Science Insights 2015; 12(1):384-390.

Received: 10 February, 2015        Revised: 02 March, 2015        Accepted: 09 March, 2015