05 JULY 2013, VOL. 1, NO. 1





05 JULY 2013, VOL. 1, NO. 1, PAGES 1-15



About the Cover: Cerebrovascular accidents, a part of the complex of vascular diseases, have its own origin. Hormone replacement therapy emerged as a supplementary therapeutic strategy for them with the potential risk of cerebrovascular accidents. Receptor plasticity was considered as an essential contributor to the receptor remodeling in postmenopausal older women (see page 9).

 




Table of Contents

EDITORS

The list of the Editors is updated every two issues. Only PDF is available.

Science Insights 2013, 1(1):1-2.

» PDF


NEWS

Worldwide break news are selected.

►Space Education (Beijing, CHINA)

►Molecular Chip (Copenhagen, DENMARK)

Space 3D Printer (Washington DC, USA)

Global Warming (Washington DC, USA)

Science Insights 2013, 1(1):3.

» Full Text    » PDF


EDITOR'S CHOICE

Recent representative literatures are highlighted.

►MICROBIOLOGY: Silver in Antimicrobes

►ECOLOGY: Moving for Foods?

►ORGANIC CHEMISTRY: Inhibitors of HSP90

Science Insights 2013, 1(1):4.

» Full Text    » PDF


EDITORIAL

►Science INSIGHTS®: the Science Journal for You

By The Editorial Office of Science INSIGHTS®

Science Insights 2013, 1(1):5-8.

» Full Text    » PDF

Summary

Science INSIGHTS® is a new launched international journal focusing on science and science education. It provides a platform for your science opinion and promotes education of science knowledge. Taking advantage of our new standards in science, you can insight the real world of science with specific view. It is a challenge for scientists to test their ideas, and it is also a challenge for educators to spread science. Science and education, both of them have the equal priority to one another in the process of advancing science knowledge. This is the very goal of Science INSIGHTS® to spread and educate science to each corner of the world.


REVIEW

►The Hormone Replacement Therapy in Cerebrovascular Diseases: Is the Receptor Remodeled?

By Yusheng Liu, Shiqin Xu, Xiaofeng Shen, Xueneng Guan, Fuzhou Wang

Science Insights 2013, 1(1):9-15.

» Full Text    » PDF

Summary

Events in cerebral vessel have long been considered as a leading cause of disability in postmenopausal women with the physiological changes in expression and secretion of sex hormones. Hormone replacement therapy (HRT) emerged as a supplementary therapeutic strategy for them with the potential risk of cerebrovascular accidents. Epidemiological and genetic data showed that an interrelationship exists between hormone replacement and cerebrovascular disorders. Many animal experiments and clinical observations produced different results: these varied from positive to negative. Furthermore, recent studies could not identify the particular hormone, estrogen or progesterone that is more beneficial than the other. Here we summarize the two hormones’ effects on cerebrovascular diseases; associated epidemiological and genetic evidences; and the real status of the benefits and risks of HRT as well. We further hypothesize that whatever effects of HRT on brain vessel, hormone receptor expression, density, sensitivity and function may undergo alteration to varying extents, i.e. receptor plasticity gives rise to the receptor remodeling in postmenopausal older women, this may terminally produce the unwelcome effects.