15 JULY 2013, VOL. 1, NO. 2


15 JULY 2013, VOL. 1, NO. 2, PAGES 16-23.

About the Cover: The Setpoint Theory of neuronal homeostatic plasticity is the key mechanism stablizing the central nervous system. In pathologic conditions, the setpoint was moved up or down that finally results in an overbalanced microenvironment. Changes in many molecular regulators like cyclooxygenase-prostaglandins contribute to the setpoint shift (see page 20).

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Science Insights 2013; 1(2): 16-17.

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Homeostatic Synaptic Plasticity: Balanced by COX2-PGE2 System to a New Setpoint

By Xiaofeng Shen, Hongmei Yuan, Wei Wang, Shiqin Xu, Haibo Wu, Xirong Guo, Fuzhou Wang

Science Insights 2013; 1(2): 20-23.

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The setpoint of neural activity plays a critical role in maintaining the complex neural circuits into stable activities. Homeostatic synaptic plasticity is a major component of the setpoint theory that dynamically adjusts synaptic strengths. Cyclooxy-genase 2 (COX 2) is rapidly upregulated in inflammatory episodes after nervous injury and its product prostaglandin E2 (PGE2) exerts contrast functions in the nervous system by working on the homeostatic plasticity. New data revealed that COX2-PGE2 system takes an essential part in balancing excitation and inhibition of the synaptic activities at a new setpoint that finally is maintained by the homeostatic synaptic plasticity.


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Science Insights 2013; 1(2): 23.

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