07 OCTOBER 2013, VOL. 3, NO. 3

   


07 OCTOBER 2013, VOL. 3, NO. 3, PAGES 57-62.




About the Cover:  GABA is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. Also GABA activation is considered as the basis of general anesthesia including intravenous and inhalational anesthetics. Meanwhile, cumulating evidence indicated that GABA is the underlying mechanism of post-operative cognitive dysfunction (POCD). Based on these findings, researchers are beginning to focus on GABA as the target to treat POCD, but they ignored the role of GABA in the performance of general anesthesia, especially when the blockade of GABA was given prior to surgery. It is undoubtedly risking our patients in intra-operative awareness. (See page 61).




Table of Contents

Cover (Only PDF is available)

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Contents (Only PDF is available)

Science Insights 2013; 3(3): page i.

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NEWS

Worldwide break news are selected.

Newfound Mount Zion “Mansion” (Jerusalem, ISREAL)

Biblical-Era Town Discovered Along Sea of Galilee (Reading, UK)

Antibiotic-Resistant Infections is Going Down (Atlanta, USA)

The Roots of Creativity (Hanover, USA)

New Battery Using Sewage (Stanford, USA)

How Much Longer Can Earth Support Life? (Norwich, UK)

Science Insights 2013; 3(3): 57-58.

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EDITOR'S CHOICE

Recent representative literatures are highlighted.

COMPUTER NETWORK: Sleep Mode and Network Effectiveness

MEDICINE: Air Pollution and Cardiovascular Risk

CANCER: Obesity and Breast Cancer: Role of CCL2

Science Insights 2013; 3(3): 59.

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PICTURE STATION

Ears of Maize, Mochica. (1-800 D.C. Apogee Epoch)

From The Larco Museum, Peru

Science Insights 2013; 3(3): 60.

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MINI-REPORT

Is It Feasible of Prophylactic α5 GABAA Receptor Blockade for Preventing POCD?

By Xiaofeng Shen, Yusheng Liu, Shiqin Xu, Rong Shen, Xirong Guo, Fuzhou Wang

Science Insights 2013; 3(3): 61-62.

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SUMMARY

Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system (CNS). It plays a role in regulating neuronal excitability throughout the nervous system. Also GABA activation is considered as the basis of general anesthesia including intravenous and inhalational anesthetics. Meanwhile, cumulating evidence indicated that GABA is the underlying mechanism of post-operative cognitive dysfunction (POCD). Based on these findings, researchers are beginning to focus on GABA as the target to treat POCD, but they ignored the role of GABA in the performance of general anesthesia, especially when the blockade of GABA was given prior to surgery. It is undoubtedly risking our patients in intra-operative awareness. Our exploratory data also verified our hypothesis in which the GABA inhibition would reduce the efficacy of inhalational anesthetics.