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Published Apr 28, 2023

Nicole Lawson

Brian Chung  

Abstract

Polymerase Epsilon (POLE)-mutant endometrial cancer accounts for 7%-12% of endometrial cancer molecular types, and most of these patients are early-stage endometrioid carcinoma. Although POLE-mutant endometrial cancer has some unfavorable pathological features such as being poorly differentiated, the overall prognosis is good, and postoperative adjuvant treatment may be considered for de-escalation. POLE-mutant endometrial cancer is relatively less sensitive to postoperative adjuvant chemotherapy or radiotherapy, but because of its ultra-high tumor mutation load, recurrent or advanced patients are expected to benefit from programmed cell death receptor 1 (PCDR1) blockade therapy. This review will discuss the clinical features of POLE-mutated endometrial carcinoma and the progress made in the detection of POLE gene mutations.

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Keywords

Endometrial Neoplasms, Molecular Classification, POLE Mutation, Prognosis, Outcomes

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How to Cite
Lawson, N., & Chung, B. (2023). Clinical Characteristics and Detection of Polymerase Epsilon Mutant Endometrial Carcinoma. Science Insights, 42(4), 903–908. https://doi.org/10.15354/si.23.re295
Section
Review