Is Stress a Contributor to Tumor Metastasis?
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Published
May 26, 2024
Abstract
Stress, often considered a silent yet pervasive force in our daily lives, has increasingly been recognized for its significant impact on human health. In the realm of oncology, the connection between stress and cancer development, particularly tumor metastasis, has become a subject of intense research and clinical interest. This review discusses the intricate relationship between stress and tumor metastasis, exploring the biological mechanisms, clinical implications, and potential therapeutic approaches at the intersection of these two complex phenomena. By understanding the role of stress in shaping cancer progression, we may uncover new avenues for improving patient outcomes and advancing cancer care.
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Keywords
Stress, Tumor Metastasis, Mechanisms, Prevention, Prognosis
References
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28. Weis J. Support groups for cancer patients. Support Care Cancer 2003; 11(12):763-768. DOI: https://doi.org/10.1007/s00520-003-0536-7
29. de Witte M, Orkibi H, Zarate R, Karkou V, Sajnani N, Malhotra B, Ho RTH, Kaimal G, Baker FA, Koch SC. From therapeutic factors to mechanisms of change in the creative arts therapies: A scoping review. Front Psychol 2021; 12:678397. DOI: https://doi.org/10.3389/fpsyg.2021.678397
30. Choi JW, Hua TNM. Impact of lifestyle behaviors on cancer risk and prevention. J Lifestyle Med 2021; 11(1):1-7. DOI: https://doi.org/10.15280/jlm.2021.11.1.1
31. Kim K, Yoon H. Health-related quality of life among cancer survivors depending on the occupational status. Int J Environ Res Public Health 2021; 18(7):3803. DOI: https://doi.org/10.3390/ijerph18073803
32. Jang A, Brown C, Lamoury G, Morgia M, Boyle F, Marr I, Clarke S, Back M, Oh B. The effects of acupuncture on cancer-related fatigue: Updated systematic review and meta-analysis. Integr Cancer Ther 2020; 19:1534735420949679. DOI: https://doi.org/10.1177/1534735420949679
33. Romero SAD, Emard N, Baser RE, Panageas K, MacLeod J, Walker D, Barton-Burke M, Liou K, Deng G, Farrar J, Xiao H, Mao JJ, Epstein A. Acupuncture versus massage for pain in patients living with advanced cancer: A protocol for the IMPACT randomised clinical trial. BMJ Open 2022; 12(9):e058281. DOI: https://doi.org/10.1136/bmjopen-2021-058281
34. Martino J, Pegg J, Frates EP. The connection prescription: Using the power of social interactions and the deep desire for connectedness to empower health and wellness. Am J Lifestyle Med 2015; 11(6):466-475. DOI: https://doi.org/10.1177/1559827615608788
35. Triozzi PL, Goldstein D, Laszlo J. Contributions of benzodiazepines to cancer therapy. Cancer Invest 1988; 6(1):103-111. DOI: https://doi.org/10.3109/07357908809077033
36. Vinkers CH, Olivier B. Mechanisms underlying tolerance after long-term benzodiazepine use: A future for subtype-selective GABA(A) receptor modulators? Adv Pharmacol Sci 2012; 2012:416864. DOI: https://doi.org/10.1155/2012/416864
37. Gosmann NP, Costa MA, Jaeger MB, Motta LS, Frozi J, Spanemberg L, Manfro GG, Cuijpers P, Pine DS, Salum GA. Selective serotonin reuptake inhib-itors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis. PLoS Med 2021; 18(6):e1003664. DOI: https://doi.org/10.1371/journal.pmed.1003664
38. Williams S, Dale J. The effectiveness of treatment for depression/depressive symptoms in adults with cancer: A systematic review. Br J Cancer 2006; 94(3):372-390. DOI: https://doi.org/10.1038/sj.bjc.6602949
39. Smith HR. Depression in cancer patients: Patho-genesis, implications and treatment (Review). Oncol Lett 2015; 9(4):1509-1514. DOI: https://doi.org/10.3892/ol.2015.2944
40. Farzam K, Jan A. Beta Blockers. [Updated 2023 Aug 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK532906/
41. Dietrich J, Rao K, Pastorino S, Kesari S. Cortico-steroids in brain cancer patients: Benefits and pit-falls. Expert Rev Clin Pharmacol 2011; 4(2):233-242. DOI: https://doi.org/10.1586/ecp.11.1
42. Yasir M, Goyal A, Sonthalia S. Corticosteroid Ad-verse Effects. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Pub-lishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK531462/
43. Haywood A, Good P, Khan S, Leupp A, Jen-kins-Marsh S, Rickett K, Hardy JR. Corticosteroids for the management of cancer-related pain in adults. Cochrane Database Syst Rev 2015; 2015(4):CD010756. DOI: https://doi.org/10.1002/14651858.CD010756.pub2
2. Cui B, Peng F, Lu J, He B, Su Q, Luo H, Deng Z, Jiang T, Su K, Huang Y, Ud Din Z, Lam EW, Kelley KW, Liu Q. Cancer and stress: NextGen strategies. Brain Behav Immun 2021; 93:368-383. DOI: https://doi.org/10.1016/j.bbi.2020.11.005
3. Obradović MMS, Hamelin B, Manevski N, Couto JP, Sethi A, Coissieux MM, Münst S, Okamoto R, Kohler H, Schmidt A, Bentires-Alj M. Glucocorti-coids promote breast cancer metastasis. Nature 2019; 567(7749):540-544. DOI: https://doi.org/10.1038/s41586-019-1019-4
4. Vignjević Petrinović S, Milošević MS, Marković D, Momčilović S. Interplay between stress and can-cer-A focus on inflammation. Front Physiol 2023; 14:1119095. DOI: https://doi.org/10.3389/fphys.2023.1119095
5. Jenkins FJ, Van Houten B, Bovbjerg DH. Effects on DNA damage and/or repair processes as biological mechanisms linking psychological stress to cancer risk. J Appl Biobehav Res 2014; 19(1):3-23. DOI: https://doi.org/10.1111/jabr.12019
6. Lempesis IG, Georgakopoulou VE, Papalexis P, Chrousos GP, Spandidos DA. Role of stress in the pathogenesis of cancer (Review). Int J Oncol 2023; 63(5):124. DOI: https://doi.org/10.3892/ijo.2023.5572
7. Tian W, Liu Y, Cao C, Zeng Y, Pan Y, Liu X, Peng Y, Wu F. Chronic stress: Impacts on tumor microen-vironment and implications for anti-cancer treat-ments. Front Cell Dev Biol 2021; 9:777018. DOI: https://doi.org/10.3389/fcell.2021.777018. Erratum in: Front Cell Dev Biol 2022; 10:865043.
8. Scheau C, Draghici C, Ilie MA, Lupu M, Solomon I, Tampa M, Georgescu SR, Caruntu A, Constantin C, Neagu M, Caruntu C. Neuroendocrine factors in melanoma pathogenesis. Cancers (Basel) 2021; 13(9):2277. DOI: https://doi.org/10.3390/cancers13092277
9. Cahn BR, Goodman MS, Peterson CT, Maturi R, Mills PJ. Yoga, Meditation and mind-body health: Increased BDNF, cortisol awakening response, and altered inflammatory marker expression after a 3-month yoga and meditation retreat. Front Hum Neurosci 2017; 11:315. DOI: https://doi.org/10.3389/fnhum.2017.00315. Erratum in: Front Hum Neurosci 2022; 16:868021. Erratum in: Front Hum Neurosci 2023; 17:1278043.
10. Nieman DC, Wentz LM. The compelling link be-tween physical activity and the body’s defense system. J Sport Health Sci 2019; 8(3):201-217. DOI: https://doi.org/10.1016/j.jshs.2018.09.009
11. Hong H, Ji M, Lai D. Chronic stress effects on tumor: Pathway and mechanism. Front Oncol 2021; 11:738252. DOI: https://doi.org/10.3389/fonc.2021.738252
12. Caiazza F, Ryan EJ, Doherty G, Winter DC, Sheahan K. Estrogen receptors and their implica-tions in colorectal carcinogenesis. Front Oncol 2015; 5:19. DOI: https://doi.org/10.3389/fonc.2015.00019
13. Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: The impact of stress and glu-cocorticoids on glutamate transmission. Nat Rev Neurosci 2011; 13(1):22-37. DOI: https://doi.org/10.1038/nrn3138
14. Schneiderman N, Ironson G, Siegel SD. Stress and health: Psychological, behavioral, and biological determinants. Annu Rev Clin Psychol 2005; 1:607-628. DOI: https://doi.org/10.1146/annurev.clinpsy.1.102803.144141
15. Powell ND, Tarr AJ, Sheridan JF. Psychosocial stress and inflammation in cancer. Brain Behav Immun 2013; 30 Suppl:S41-S47. DOI: https://doi.org/10.1016/j.bbi.2012.06.015
16. Grajek M, Krupa-Kotara K, Białek-Dratwa A, Sob-czyk K, Grot M, Kowalski O, Staśkiewicz W. Nu-trition and mental health: A review of current knowledge about the impact of diet on mental health. Front Nutr 2022; 9:943998. DOI: https://doi.org/10.3389/fnut.2022.943998
17. Cook JL, Russell K, Long A, Phipps S. Centrality of the childhood cancer experience and its relation to post-traumatic stress and growth. Psychooncology 2021; 30(4):564-570. DOI: https://doi.org/10.1002/pon.5603
18. Chiriac VF, Baban A, Dumitrascu DL. Psychological stress and breast cancer incidence: A systematic review. Clujul Med 2018; 91(1):18-26. DOI: https://doi.org/10.15386/cjmed-924
19. Dai S, Mo Y, Wang Y, Xiang B, Liao Q, Zhou M, Li X, Li Y, Xiong W, Li G, Guo C, Zeng Z. Chronic stress promotes cancer development. Front Oncol 2020; 10:1492. DOI: https://doi.org/10.3389/fonc.2020.01492
20. Herrera-Martínez AD, Román ÁR, Corrales EP, Idrobo C, Ramírez PP, Rojas PM, Lázaro CR, Araujo-Castro M. Adrenal incidentalomas, cortisol secretion and cancer: is there a real crosstalk? Front Endocrinol (Lausanne) 2024; 14:1335202. DOI: https://doi.org/10.3389/fendo.2023.1335202
21. Antonova L, Aronson K, Mueller CR. Stress and breast cancer: From epidemiology to molecular bi-ology. Breast Cancer Res 2011; 13(2):208. DOI: https://doi.org/10.1186/bcr2836
22. Beurel E. Stress in the microbiome-immune crosstalk. Gut Microbes 2024; 16(1):2327409. DOI: https://doi.org/10.1080/19490976.2024.2327409
23. Chen M, Singh AK, Repasky EA. Highlighting the potential for chronic stress to minimize therapeutic responses to radiotherapy through increased im-munosuppression and radiation resistance. Cancers (Basel) 2020; 12(12):3853. DOI: https://doi.org/10.3390/cancers12123853
24. Chen Y, Tan F, Wei L, Li X, Lyu Z, Feng X, Wen Y, Guo L, He J, Dai M, Li N. Sleep duration and the risk of cancer: A systematic review and meta-analysis including dose-response relationship. BMC Cancer 2018; 18(1):1149. DOI: https://doi.org/10.1186/s12885-018-5025-y
25. Collatuzzo G, Pelucchi C, Negri E, Kogevinas M, Huerta JM, Vioque J, de la Hera MG, Tsugane S, Shigueaki Hamada G, Hidaka A, Zhang ZF, Ca-margo MC, Curado MP, Lunet N, La Vecchia C, Boffetta P. Sleep duration and stress level in the risk of gastric cancer: A pooled analysis of case-control studies in the stomach cancer pooling (StoP) project. Cancers (Basel) 2023; 15(17):4319. DOI: https://doi.org/10.3390/cancers15174319
26. Lin C, Tian H, Chen L, Yang Q, Wu J, Ji Z, Zheng D, Li Z, Xie Y. The efficacy of cognitive behavioral therapy for cancer: A scientometric analysis. Front Psychiatry 2022; 13:1030630. DOI: https://doi.org/10.3389/fpsyt.2022.1030630
27. Rush SE, Sharma M. Mindfulness-based stress reduction as a stress management intervention for cancer care: A systematic review. J Evid Based Complementary Altern Med 2017; 22(2):348-360. DOI: https://doi.org/10.1177/2156587216661467
28. Weis J. Support groups for cancer patients. Support Care Cancer 2003; 11(12):763-768. DOI: https://doi.org/10.1007/s00520-003-0536-7
29. de Witte M, Orkibi H, Zarate R, Karkou V, Sajnani N, Malhotra B, Ho RTH, Kaimal G, Baker FA, Koch SC. From therapeutic factors to mechanisms of change in the creative arts therapies: A scoping review. Front Psychol 2021; 12:678397. DOI: https://doi.org/10.3389/fpsyg.2021.678397
30. Choi JW, Hua TNM. Impact of lifestyle behaviors on cancer risk and prevention. J Lifestyle Med 2021; 11(1):1-7. DOI: https://doi.org/10.15280/jlm.2021.11.1.1
31. Kim K, Yoon H. Health-related quality of life among cancer survivors depending on the occupational status. Int J Environ Res Public Health 2021; 18(7):3803. DOI: https://doi.org/10.3390/ijerph18073803
32. Jang A, Brown C, Lamoury G, Morgia M, Boyle F, Marr I, Clarke S, Back M, Oh B. The effects of acupuncture on cancer-related fatigue: Updated systematic review and meta-analysis. Integr Cancer Ther 2020; 19:1534735420949679. DOI: https://doi.org/10.1177/1534735420949679
33. Romero SAD, Emard N, Baser RE, Panageas K, MacLeod J, Walker D, Barton-Burke M, Liou K, Deng G, Farrar J, Xiao H, Mao JJ, Epstein A. Acupuncture versus massage for pain in patients living with advanced cancer: A protocol for the IMPACT randomised clinical trial. BMJ Open 2022; 12(9):e058281. DOI: https://doi.org/10.1136/bmjopen-2021-058281
34. Martino J, Pegg J, Frates EP. The connection prescription: Using the power of social interactions and the deep desire for connectedness to empower health and wellness. Am J Lifestyle Med 2015; 11(6):466-475. DOI: https://doi.org/10.1177/1559827615608788
35. Triozzi PL, Goldstein D, Laszlo J. Contributions of benzodiazepines to cancer therapy. Cancer Invest 1988; 6(1):103-111. DOI: https://doi.org/10.3109/07357908809077033
36. Vinkers CH, Olivier B. Mechanisms underlying tolerance after long-term benzodiazepine use: A future for subtype-selective GABA(A) receptor modulators? Adv Pharmacol Sci 2012; 2012:416864. DOI: https://doi.org/10.1155/2012/416864
37. Gosmann NP, Costa MA, Jaeger MB, Motta LS, Frozi J, Spanemberg L, Manfro GG, Cuijpers P, Pine DS, Salum GA. Selective serotonin reuptake inhib-itors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis. PLoS Med 2021; 18(6):e1003664. DOI: https://doi.org/10.1371/journal.pmed.1003664
38. Williams S, Dale J. The effectiveness of treatment for depression/depressive symptoms in adults with cancer: A systematic review. Br J Cancer 2006; 94(3):372-390. DOI: https://doi.org/10.1038/sj.bjc.6602949
39. Smith HR. Depression in cancer patients: Patho-genesis, implications and treatment (Review). Oncol Lett 2015; 9(4):1509-1514. DOI: https://doi.org/10.3892/ol.2015.2944
40. Farzam K, Jan A. Beta Blockers. [Updated 2023 Aug 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK532906/
41. Dietrich J, Rao K, Pastorino S, Kesari S. Cortico-steroids in brain cancer patients: Benefits and pit-falls. Expert Rev Clin Pharmacol 2011; 4(2):233-242. DOI: https://doi.org/10.1586/ecp.11.1
42. Yasir M, Goyal A, Sonthalia S. Corticosteroid Ad-verse Effects. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Pub-lishing; 2024 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK531462/
43. Haywood A, Good P, Khan S, Leupp A, Jen-kins-Marsh S, Rickett K, Hardy JR. Corticosteroids for the management of cancer-related pain in adults. Cochrane Database Syst Rev 2015; 2015(4):CD010756. DOI: https://doi.org/10.1002/14651858.CD010756.pub2
How to Cite
Singh, S. (2024). Is Stress a Contributor to Tumor Metastasis?. Science Insights, 44(5), 1375–1380. https://doi.org/10.15354/si.24.re1007
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