Monoamine Neurotransmitters and Drug Addiction
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Published
Mar 29, 2023
Abstract
Drug addiction is a chronic, relapsing brain disease. Various addictive drugs act on the reward circuit and eventually cause changes in the release of neurotransmitters, resulting in a rewarding effect. Among them, the monoamine neurotransmitters 5-hydroxytryptamine, norepinephrine and dopamine play an essential role in drug addiction. The role and mechanism of monoamine neurotransmitters in drug addiction are reviewed and discussed.
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Keywords
Drug Addiction, Monoamine Neurotransmitter, Serotonin, Norepinephrine, Dopamine, Reward Circuit
References
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5. Yohn CN, Gergues MM, Samuels BA. The role of 5-HT receptors in depression. Mol Brain 2017; 10(1):28. DOI: https://doi.org/10.1186/s13041-017-0306-y
6. Porras G, Di Matteo V, Fracasso C, Lucas G, De Deurwaerdère P, Caccia S, Esposito E, Spampinato U. 5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 2002; 26(3):311-324. DOI: https://doi.org/10.1016/S0893-133X(01)00333-5
7. Dunn KE, Huhn AS, Bergeria CL, Gipson CD, Weerts EM. Non-opioid neurotransmitter systems that contribute to the opioid withdrawal syndrome: A review of preclinical and human evidence. J Pharmacol Exp Ther 2019; 371(2):422-452. DOI: https://doi.org/10.1124/jpet.119.258004
8. Li B, Jiang J, Zhou L, Tao X, Sun Q, Liu J, Liu Y, Pang G. Blockade of 5-hydroxytryptamine 2A receptor attenuates precipitation of naloxone-induced withdrawal symptoms in opioid-exposed mice. Front Behav Neurosci 2022; 15:797217. DOI: https://doi.org/10.3389/fnbeh.2021.797217
9. Kosten TR, George TP. The neurobiology of opioid dependence: Implications for treatment. Sci Pract Perspect 2002; 1(1):13-20. DOI: https://doi.org/10.1151/spp021113
10. Alex KD, Pehek EA. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 2007; 113(2):296-320. DOI: https://doi.org/10.1016/j.pharmthera.2006.08.004
11. Thomas DM, Angoa Pérez M, Francescutti-Verbeem DM, Shah MM, Kuhn DM. The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. J Neurochem 2010; 115(3):595-605. DOI: https://doi.org/10.1111/j.1471-4159.2010.06950.x
12. Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD. Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Br J Pharmacol 2017; 174(16):2716-2738. DOI: https://doi.org/10.1111/bph.13899
13. Krasnova IN, Cadet JL. Methamphetamine toxicity and messengers of death. Brain Res Rev 2009; 60(2):379-407. DOI: https://doi.org/10.1016/j.brainresrev.2009.03.002
14. Dunlap LE, Andrews AM, Olson DE. Dark classics in chemical neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci 2018; 9(10):2408-2427. DOI: https://doi.org/10.1021/acschemneuro.8b00155
15. Huff C, Bhide N, Schroering A, Yamamoto BK, Gudelsky GA. Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake. Brain Res Bull 2013; 91:52-7. DOI: https://doi.org/10.1016/j.brainresbull.2013.01.003
16. Lizarraga LE, Phan AV, Cholanians AB, Herndon JM, Lau SS, Monks TJ. Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats. Toxicol Sci 2014; 139(2):421-431. DOI: https://doi.org/10.1093/toxsci/kfu039
17. Mateo Y, Budygin EA, John CE, Jones SR. Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. Proc Natl Acad Sci USA 2004; 101(1):372-377. DOI: https://doi.org/10.1073/pnas.0207805101
18. Howell LL, Cunningham KA. Serotonin 5-HT2 receptor interactions with dopamine function: Implications for therapeutics in cocaine use disorder. Pharmacol Rev 2015; 67(1):176-197. DOI: https://doi.org/10.1124/pr.114.009514
19. Nestler EJ. The neurobiology of cocaine addiction. Sci Pract Perspect 2005; 3(1):4-10. DOI: https://doi.org/10.1151/spp05314
20. Juárez Olguín H, Calderón Guzmán D, Hernández García E, Barragán Mejía G. The Role of dopamine and its dysfunction as a consequence of oxidative stress. Oxid Med Cell Longev 2016; 2016:9730467. DOI: https://doi.org/10.1155/2016/9730467
21. Doyle MA, Mazei-Robison MS. Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons. Cold Spring Harb Perspect Med 2021; 11(2):a039362. DOI: https://doi.org/10.1101/cshperspect.a039362
22. Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW. The nucleus accumbens: Mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacol Rev. 2016 Jul; 68(3):816-871. DOI: https://doi.org/10.1124/pr.116.012484
23. George BE, Dawes MH, Peck EG, Jones SR. Altered accumbal dopamine terminal dynamics following chronic heroin self-administration. Int J Mol Sci 2022; 23(15):8106. DOI: https://doi.org/10.3390/ijms23158106
24. Cheng GL, Liu YP, Chan CC, So KF, Zeng H, Lee TM. Neurobiological underpinnings of sensation seeking trait in heroin abusers. Eur Neuropsychopharmacol 2015; 25(11):1968-80. DOI: https://doi.org/10.1016/j.euroneuro.2015.07.023
25. Li GZ, Liu ZH, Wei X, Zhao P, Yang CX, Xu MY. Effect of acetylcholine receptors on the pain-related electrical activities in the hippocampal CA3 region of morphine-addicted rats. Iran J Basic Med Sci 2015; 18(7):664-671
26. Chen M, Zhao Y, Yang H, Luan W, Song J, Cui D, Dong Y, Lai B, Ma L, Zheng P. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife 2015; 4:e09275. DOI: https://doi.org/10.7554/eLife.09275
27. Shah M, Huecker MR. Opioid withdrawal. [Updated 2022 Sep 9]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. Available at: https://www.ncbi.nlm.nih.gov/books/NBK526012/
28. Mazei-Robison MS, Nestler EJ. Opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons. Cold Spring Harb Perspect Med 2012; 2(7):a012070. DOI: https://doi.org/10.1101/cshperspect.a012070
29. Gao JT, Jordan CJ, Bi GH, He Y, Yang HJ, Gardner EL, Xi ZX. Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats. Neuropsychopharmacology 2018; 43(13):2615-2626. DOI: https://doi.org/10.1038/s41386-018-0231-5
30. Cai J, Tong Q. Anatomy and function of ventral tegmental area glutamate neurons. Front Neural Circuits 2022; 16:867053. DOI: https://doi.org/10.3389/fncir.2022.867053
31. Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F. Addiction: Beyond dopamine reward circuitry. Proc Natl Acad Sci USA 2011; 108(37):15037-15042. DOI: https://doi.org/10.1073/pnas.1010654108
32. Zhu F, Liu L, Li J, Liu B, Wang Q, Jiao R, Xu Y, Wang L, Sun S, Sun X, Younus M, Wang C, Hokfelt T, Zhang B, Gu H, Xu ZD, Zhou Z. Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Rep 2022; 40(7):111199. DOI: https://doi.org/10.1016/j.celrep.2022.111199
33. Čechová B, Šlamberová R. Methamphetamine, neurotransmitters and neurodevelopment. Physiol Res 2021; 70(S3):S301-S315. DOI: https://doi.org/10.33549/physiolres.934821
34. Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP. The vesicular monoamine transporter-2: An important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Adv Pharmacol 2014; 69:71-106. DOI: https://doi.org/10.1016/B978-0-12-420118-7.00002-0
35. Everitt BJ. Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction. Eur J Neurosci 2014; 40(1):2163-2182. DOI: https://doi.org/10.1111/ejn.12644
36. Volkow ND, Michaelides M, Baler R. The neuroscience of drug reward and addiction. Physiol Rev 2019; 99(4):2115-2140. DOI: https://doi.org/10.1152/physrev.00014.2018
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How to Cite
Zimny, E. (2023). Monoamine Neurotransmitters and Drug Addiction. Science Insights, 42(3), 837–842. https://doi.org/10.15354/si.23.re216
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